Article
Somatic hypermutations in the immunoglobulin genes of two new human lymphoma lines of lymphatic follicle origin.
Scandinavian journal of immunology - 1 Mar 1994
Wu H Y, Tuomikoski T, Eray M, Mattila P, Knuutila S, Kaartinen M
Abstract excerpt
Variable immunoglobulin heavy-chain regions (VDJ) of two newly established human lymphoma cell lines (HF-1 and HF-4) were sequenced. The most homologous germline VH gene found for both the HF-1 and HF-4 sequences was VH26 of the VH3a (V gene) family (82% and 91% homologies, respectively). The JH region of the HF-4 heavy-chain sequence contained two nucleotide differences compared to the published germline JH3...
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