Article
Somatic hypermutations in the immunoglobulin genes of two new human lymphoma lines of lymphatic follicle origin.
Scandinavian journal of immunology - 1 Mar 1994
Wu H Y, Tuomikoski T, Eray M, Mattila P, Knuutila S, Kaartinen M
Abstract excerpt
Variable immunoglobulin heavy-chain regions (VDJ) of two newly established human lymphoma cell lines (HF-1 and HF-4) were sequenced. The most homologous germline VH gene found for both the HF-1 and HF-4 sequences was VH26 of the VH3a (V gene) family (82% and 91% homologies, respectively). The JH...
Topics
- Base Sequence
- Chromosomes, Human, Pair 14
- Chromosomes, Human, Pair 18
- Genes, Immunoglobulin
- Humans
- Immunoglobulin Heavy Chains
- Immunoglobulin J-Chains
- Lymphoma, Follicular
- Molecular Sequence Data
- Mutation
- RNA, Messenger
- Translocation, Genetic
- Tumor Cells, Cultured