Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Somatic hypermutation of immunoglobulin variable region genes: focus on follicular lymphoma and multiple myeloma.

Immunological reviews - 1 Apr 1998

Kosmas C, Stamatopoulos K, Papadaki T, Belessi C, Yataganas X, Anagnostou D, Loukopoulos D

Abstract excerpt

Analysis of the rearranged immunoglobulin variable region gene hypermutation has provided important information concerning the clonal history and ontogenetic origin of various B-cell lymphoproliferative disorders. Under the selective pressure of antigen, mutational events in immunoglobulin genes will fine tune survival of B-cell clones bearing immunoglobulin with high affinity for antigen. Our studies aimed at...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Amino Acid Sequence
Share to Base Sequence

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Gene Rearrangement

Share to Immunoglobulin Heavy Chains

Share to Immunoglobulin Variable Region

Share to Molecular Sequence Data

Share to Multiple Myeloma

Share to Mutation

Source

Identifiers

PMID: 9602371
DOI: 10.1111/j.1600-065x.1998.tb01448.x

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Somatic hypermutation of immunoglobulin variable region genes: focus on follicular lymphoma and multiple myeloma.PMID 9602371Read ↗

The genetic variability of the VH genes in follicular lymphoma: the impact of the hypermutation mechanism.Semantic proximity Read ↗

Follicular lymphoma immunoglobulin kappa light chains are affected by the antigen selection process, but to a lesser degree than their partner heavy chains.Semantic proximity Read ↗

Variable heavy chain gene analysis of follicular lymphomas: correlation between heavy chain isotype expression and somatic mutation load.Semantic proximity Read ↗

Myeloma VL and VH Gene Sequences Reveal a Complementary Imprint of Antigen Selection in Tumor CellsSemantic proximity Read ↗

The roles of antibody variable region hypermutation and selection in the development of the memory B-cell compartment.Semantic proximity Read ↗

Clonal history of a human follicular lymphoma as revealed in the immunoglobulin variable region genes.Semantic proximity Read ↗

Clonal evolution of a follicular lymphoma: evidence for antigen selection.Semantic proximity Read ↗

High Throughput Sequencing Analysis of the Immunoglobulin Heavy Chain Gene from Flow-Sorted B Cell Sub-Populations Define the Dynamics of Follicular Lymphoma Clonal Evolution.Semantic proximity Read ↗

B Cell Receptor Immunogenetics in B Cell Lymphomas: Immunoglobulin Genes as Key to Ontogeny and Clinical Decision MakingSemantic proximity Read ↗

Is there a role for antigen selection in mantle cell lymphoma? Immunogenetic support from a series of 807 casesSemantic proximity Read ↗

Analysis of variable heavy and light chain genes in follicular lymphomas of different heavy chain isotype.Semantic proximity Read ↗

Immunoglobulin VH gene expression among extranodal marginal zone B-cell lymphomas of the ocular adnexa.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.