Article
Re-entry of tumour B cells into the cycle of somatic mutation and isotype switching in follicular lymphoma.
British journal of haematology - 1 Feb 2003
Shiokawa Satoshi, Matsushima Takamitsu, Choi Ilseung, Abe Yasunobu, Shiratsuchi Motoaki, Suehiro Youko, Muta Koichiro, Ohshima Koichi, Nishimura Junji
Abstract excerpt
Sequencing of the immunoglobulin (Ig) gene transcripts of the tumour B cells in lymph node (LN) and bone marrow (BM) from a follicular lymphoma (FL) patient associated with multiple myeloma identified two dominant clones. One of the clones, present in both LN and BM, had somatic mutations and extensive clonal diversity. Among the diversified clones, two dominant populations of identical sequences (group I and II)...
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