Article
The somatic hypermutation activity of a follicular lymphoma links to large insertions and deletions of immunoglobulin genes.
Scandinavian journal of immunology - 1 Jul 1995
Wu H Y, Kaartinen M
Abstract excerpt
A biopsy specimen from a patient with follicular lymphoma was divided into two fragments. DNA was extracted from one fragment and a 1.2 kb region of the functional heavy chain (IgH) gene was amplified, cloned and sequenced (eight clones). From the other fragment a cell line (HF-1) was started. Th...
Topics
- Base Sequence
- Gene Deletion
- Gene Rearrangement, B-Lymphocyte
- Genes, Immunoglobulin
- Genetic Heterogeneity
- Genetic Variation
- Humans
- Immunoglobulin Heavy Chains
- Lymphoma, Follicular
- Molecular Sequence Data
- Mutation
- Polymorphism, Genetic
- Selection, Genetic
- Tumor Cells, Cultured