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Article

Induction of somatic mutation in a human B cell line in vitro.

Immunity - 1 Jan 1997

Denépoux S, Razanajaona D, Blanchard D, Meffre G, Capra J D, Banchereau J, Lebecque S

Abstract excerpt

Both the B cell-surface trigger(s) and the intracellular molecular mechanism(s) of somatic hypermutation in immunoglobulin (Ig) variable region genes remain unknown, partly because of the lack of a simple and reproducible in vitro model. Here, we show that upon surface immunoglobulin cross-linking followed by co-culture with activated cloned T cells, the Burkitt's lymphoma cell line BL2 is induced to mutate its...

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Identifiers

PMID: 9052835
DOI: 10.1016/s1074-7613(00)80240-x

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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