Article
Induction of somatic mutation in a human B cell line in vitro.
Immunity - 1 Jan 1997
Denépoux S, Razanajaona D, Blanchard D, Meffre G, Capra J D, Banchereau J, Lebecque S
Abstract excerpt
Both the B cell-surface trigger(s) and the intracellular molecular mechanism(s) of somatic hypermutation in immunoglobulin (Ig) variable region genes remain unknown, partly because of the lack of a simple and reproducible in vitro model. Here, we show that upon surface immunoglobulin cross-linkin...
Topics
- Amino Acid Sequence
- Antibody Affinity
- Antigens
- B-Lymphocytes
- Base Sequence
- Burkitt Lymphoma
- Cell Division
- Clone Cells
- Genes, Immunoglobulin
- Humans
- Immunoglobulin M
- Immunoglobulin Variable Region
- Immunoglobulin mu-Chains
- Lymphocyte Activation
- Molecular Sequence Data
- Mutation
- Receptor Aggregation
- Receptors, Antigen, B-Cell