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Article

Hypermutation in human B cells in vivo and in vitro.

Annals of the New York Academy of Sciences - 1 Apr 2003

Weller Sandra, Faili Ahmad, Aoufouchi Said, Guéranger Quetin, Braun Moritz, Reynaud Claude-Agnès, Weill Jean-Claude

Abstract excerpt

We develop our previous observation that a subpopulation of circulating memory IgM(+)IgD(+)CD27(+)B cells belongs to a separate pathway of differentiation in humans. This subpopulation, which represents 5-25% of peripheral B cells, is also present in spleen in the same proportion and displays a marginal-zone-like B cell phenotype. In addition, we describe a short-time in vitro induction model for somatic...

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PMID: 12727635
DOI: 10.1111/j.1749-6632.2003.tb06044.x

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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