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Article

Evidence for a role of MEK and MAPK during signal transduction by protein kinase C zeta.

The EMBO journal - 15 Dec 1995

Berra E, Díaz-Meco M T, Lozano J, Frutos S, Municio M M, Sánchez P, Sanz L, Moscat J

Abstract excerpt

Protein kinase C zeta (zeta PKC) is critically involved in the control of a number of cell functions, including proliferation and nuclear factor kappa B (NF-kappa B) activation. Previous studies indicate that zeta PKC is an important step downstream of Ras in the mitogenic cascade. The stimulation of Ras initiates a kinase cascade that culminates in the activation of MAP kinase (MAPK), which is required for cell...

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Identifiers

PMID: 8557035
DOI: 10.1002/j.1460-2075.1995.tb00306.x
PMCID: PMC394740

Genes

TNF

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Evidence for a role of MEK and MAPK during signal transduction by protein kinase C zeta.PMID 8557035Read ↗

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Protein kinase C activates the MEK-ERK pathway in a manner independent of Ras and dependent on Raf.Semantic proximity Read ↗

Reciprocal regulation of protein kinase C isoforms results in differential cellular responsiveness.Semantic proximity Read ↗

Novel roles of specific isoforms of protein kinase C in activation of the c-fos serum response element.Semantic proximity Read ↗

Activation of NF-kappa B by oncogenic Raf in HEK 293 cells occurs through autocrine recruitment of the stress kinase cascade.Semantic proximity Read ↗

Targeted disruption of the zetaPKC gene results in the impairment of the NF-kappaB pathway.Semantic proximity Read ↗

Regulation of the MAP kinase cascade.Semantic proximity Read ↗

Independence of protein kinase C-delta activity from activation loop phosphorylation: structural basis and altered functions in cells.Semantic proximity Read ↗

Identification of MEKK2/3 serine phosphorylation site targeted by the Toll-like receptor and stress pathways.Semantic proximity Read ↗

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A subdomain of MEKK1 that is critical for binding to MKK4.Semantic proximity Read ↗

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