Article
Targeted disruption of the zetaPKC gene results in the impairment of the NF-kappaB pathway.
Molecular cell - 1 Oct 2001
Leitges M, Sanz L, Martin P, Duran A, Braun U, García J F, Camacho F, Diaz-Meco M T, Rennert P D, Moscat J
Abstract excerpt
Here we have addressed the role that zetaPKC plays in NF-kappaB activation using mice in which this kinase was inactivated by homologous recombination. These mice, although grossly normal, showed phenotypic alterations in secondary lymphoid organs reminiscent of those of the TNF receptor-1 and of the lymphotoxin-beta receptor gene-deficient mice. The lack of zetaPKC in embryonic fibroblasts (EFs) severely impairs...
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