Article
Novel roles of specific isoforms of protein kinase C in activation of the c-fos serum response element.
Molecular and cellular biology - 1 Feb 1999
Soh J W, Lee E H, Prywes R, Weinstein I B
Abstract excerpt
Protein kinase C (PKC) is a multigene family of enzymes consisting of at least 11 isoforms. It has been implicated in the induction of c-fos and other immediate response genes by various mitogens. The serum response element (SRE) in the c-fos promoter is necessary and sufficient for induction of transcription of c-fos by serum, growth factors, and the phorbol ester 12-O-tetradecanoylphorbol-13-acetate (TPA). It...
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