Article
Novel roles of specific isoforms of protein kinase C in activation of the c-fos serum response element.
Molecular and cellular biology - 1 Feb 1999
Soh J W, Lee E H, Prywes R, Weinstein I B
Abstract excerpt
Protein kinase C (PKC) is a multigene family of enzymes consisting of at least 11 isoforms. It has been implicated in the induction of c-fos and other immediate response genes by various mitogens. The serum response element (SRE) in the c-fos promoter is necessary and sufficient for induction of...
Topics
- 3T3 Cells
- Animals
- Base Sequence
- Binding Sites
- COS Cells
- Gene Expression Regulation
- Genes, fos
- Humans
- Isoenzymes
- MAP Kinase Kinase 1
- MAP Kinase Kinase 4
- MAP Kinase Kinase Kinase 1
- Mice
- Mitogen-Activated Protein Kinase Kinases
- Mutation
- Plasmids
- Promoter Regions, Genetic
- Protein Kinase C