Article
Mechanism of p38 MAP kinase activation in vivo.
Genes & development - 15 Aug 2003
Brancho Deborah, Tanaka Nobuyuki, Jaeschke Anja, Ventura Juan-Jose, Kelkar Nyaya, Tanaka Yoshinori, Kyuuma Masanao, Takeshita Toshikazu, Flavell Richard A, Davis Roger J
Abstract excerpt
The p38 mitogen-activated protein kinase (MAPK) is activated in vitro by three different protein kinases: MKK3, MKK4, and MKK6. To examine the relative roles of these protein kinases in the mechanism of p38 MAP kinase activation in vivo, we examined the effect of disruption of the murine Mkk3, Mkk4, and Mkk6 genes on the p38 MAPK signaling pathway. We show that MKK3 and MKK6are essential for tumor necrosis...
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