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Article

Independence of protein kinase C-delta activity from activation loop phosphorylation: structural basis and altered functions in cells.

The Journal of biological chemistry - 28 Apr 2006

Liu Yin, Belkina Natalya V, Graham Caroline, Shaw Stephen

Abstract excerpt

Activation loop phosphorylation plays critical regulatory roles for many kinases. Unlike other protein kinase Cs (PKC), PKC-delta does not require phosphorylation of its activation loop (Thr-507) for in vitro activity. We investigated the structural basis for this unusual capacity and its relevance to PKC-delta function in intact cells. Mutational analysis demonstrated that activity without Thr-507...

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Identifiers

PMID: 16505477
DOI: 10.1074/jbc.M600508200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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