Article
Activation of NF-kappa B by oncogenic Raf in HEK 293 cells occurs through autocrine recruitment of the stress kinase cascade.
Oncogene - 13 Aug 1998
Troppmair J, Hartkamp J, Rapp U R
Abstract excerpt
Raf-1 kinase has been implicated in the induction of NF-kappa B activity by serum growth factors, phorbol ester and PTK oncogenes. Here we show that Raf activation of NF-kappa B, as measured in reporter gene assays, occurs indirectly and requires the stress kinase cascade. The stress pathway pres...
Topics
- 3T3 Cells
- Animals
- Autocrine Communication
- Calcium-Calmodulin-Dependent Protein Kinases
- Enzyme Activation
- ErbB Receptors
- Gene Expression Regulation
- Genes, Reporter
- Humans
- JNK Mitogen-Activated Protein Kinases
- MAP Kinase Kinase Kinase 1
- Mice
- Mitogen-Activated Protein Kinases
- Mutation
- NF-kappa B
- Nitriles
- Protein Kinases
- Protein Serine-Threonine Kinases