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Article

Identification of MEKK2/3 serine phosphorylation site targeted by the Toll-like receptor and stress pathways.

The EMBO journal - 11 Jan 2006

Zhang Dongyu, Facchinetti Valeria, Wang Xiaofang, Huang Qiaojia, Qin Jun, Su Bing

Abstract excerpt

Members of the mitogen-activated protein kinase kinase kinase (MAP3K) family are crucial for the Toll-like receptor (TLR) signaling and cellular stress responses. However, the molecular mechanisms underlying the TLR- and cellular stress-mediated MAP3K activation remain largely unknown. In this study, we identified a key regulatory phosphorylation site, serine 519 and serine 526, in MAP3K MEKK2 and MEKK3,...

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Identifiers

PMID: 16362041
DOI: 10.1038/sj.emboj.7600913
PMCID: PMC1356356

Genes

TRAF6

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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