Article
A subdomain of MEKK1 that is critical for binding to MKK4.
Cellular signalling - 1 Jan 2003
Tu Zheng, Mooney Sharon M, Lee Frank S
Abstract excerpt
Mitogen-activated protein kinase (MAPK) cascades are central components of signal transduction pathways induced by mitogens and stresses. They consist of a three-kinase module in which a mitogen-activated protein kinase kinase kinase (MAP3K) activates a mitogen-activated protein kinase kinase (MAP2K), which in turn activates MAPK. The molecular determinants that underlie specific MAP3K-MAP2K interactions are...
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