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Article

Reciprocal regulation of protein kinase C isoforms results in differential cellular responsiveness.

Journal of immunology (Baltimore, Md. : 1950) - 1 Mar 2012

Sudan Raki, Srivastava Neetu, Pandey Surya Prakash, Majumdar Subrata, Saha Bhaskar

Abstract excerpt

Immunological homeostasis is often maintained by counteractive functions of two different cell types or two different receptors signaling through different intermediates in the same cell. One of these signaling intermediates is protein kinase C (PKC). Ten differentially regulated PKC isoforms are integral to receptor-triggered responses in different cells. So far, eight PKC isoforms are reported to be expressed...

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Identifiers

PMID: 22271653
DOI: 10.4049/jimmunol.1101678

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