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Article

Essential role of RelA Ser311 phosphorylation by zetaPKC in NF-kappaB transcriptional activation.

The EMBO journal - 1 Aug 2003

Duran Angeles, Diaz-Meco María T, Moscat Jorge

Abstract excerpt

The activation of the transcription factor NF-kappaB is central to the control of the cellular response triggered by many stimuli. Once released from the inhibitory molecule IkappaB, NF-kappaB is translocated to the nucleus, and it has to be phosphorylated to activate transcription. In zeta protein kinase C (PKC)-deficient cells, NF-kappaB is transcriptionally inactive and the phosphorylation of the RelA subunit...

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Identifiers

PMID: 12881425
DOI: 10.1093/emboj/cdg370
PMCID: PMC169043

Genes

TNF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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