Article
A dominant negative protein kinase C zeta subspecies blocks NF-kappa B activation.
Molecular and cellular biology - 1 Aug 1993
Diaz-Meco M T, Berra E, Municio M M, Sanz L, Lozano J, Dominguez I, Diaz-Golpe V, Lain de Lera M T, Alcamí J, Payá C V, Arenzana-Seisedos F, Virelizier J L, Moscat J
Abstract excerpt
Nuclear factor kappa B (NF-kappa B) plays a critical role in the regulation of a number of genes. NF-kappa B is a heterodimer of 50- and 65-kDa subunits sequestered in the cytoplasm complexed to inhibitory protein I kappa B. Following stimulation of cells, I kappa B dissociates from NF-kappa B, allowing its translocation to the nucleus, where it carries out the transactivation function. The precise mechanism...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.