Article
Regulation of the MAP kinase cascade.
Cellular & molecular biology research - 1 Jan 1994
Cobb M H, Xu S, Hepler J E, Hutchison M, Frost J, Robbins D J
Abstract excerpt
The MAP kinase cascade is regulated by many hormones and growth factors and its activation leads to changes in properties of cytoplasmic, membrane-associated, and nuclear proteins. The MAP kinases themselves are activated by MEKS. MEKs lie at a point of convergence for multiple upstream signals, mediated by distinct protein kinases, Raf, MEK kinase, and Mos, all of which have MEK kinase activity. Additional...
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