Double mutations of the N-ras gene in a patient with acute myelomonocytic leukemia.

doi:10.1016/0925-5710(95)00366-z

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Article

Double mutations of the N-ras gene in a patient with acute myelomonocytic leukemia.

International journal of hematology - 1 Jun 1995

Horiike S, Misawa S, Kaneko H, Nakai H, Ueda Y, Nakao M, Hirakawa K, Taniwaki M, Kashima K

Abstract excerpt

We report a patient with acute myelomonocytic leukemia (AMMoL) who showed two independent point mutations of the N-ras gene at codons 12 and 13. Longitudinal analysis revealed that one mutation at codon 13 was detectable throughout his disease course and the other at codon 12 emerged as a second...

Topics

Aclarubicin
Alleles
Antineoplastic Combined Chemotherapy Protocols
Chromosome Deletion
Chromosomes, Human, Pair 12
Chromosomes, Human, Pair 9
Codon
Cytarabine
Daunorubicin
Disease Progression
Doxorubicin

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Etoposide

Fatal Outcome

Genes, ras

Genetic Vectors

Humans

Karyotyping

Leukemia, Myelomonocytic, Acute

Source

Open in PubMed

Identifiers

PMID: 8547609
DOI: 10.1016/0925-5710(95)00366-z

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-8547609-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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