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Article

Longitudinal analysis of point mutations of the N-ras proto-oncogene in patients with myelodysplasia using archived blood smears.

Blood - 1 Mar 1992

van Kamp H, de Pijper C, Verlaan-de Vries M, Bos J L, Leeksma C H, Kerkhofs H, Willemze R, Fibbe W E, Landegent J E

Abstract excerpt

We performed a longitudinal analysis of point mutations of the N-ras proto-oncogene in patients with myelodysplasia and a follow-up of at least 2.5 years after diagnosis. Point mutations at codons 12, 13, and 61 of the N-ras oncogene were analyzed after in vitro amplification of N-ras specific sequences followed by dot-blot hybridization. Lysed cells scraped from archived blood and bone marrow smears were used as...

Topics

Aged
Aged, 80 and over
Bone Marrow
Codon
Female
Genes, ras
Glass
Humans
Karyotyping
Male
Middle Aged
Mutation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Myelodysplastic Syndromes

Nucleic Acid Hybridization

Polymerase Chain Reaction

Proto-Oncogene Mas

Time Factors

Source

Identifiers

PMID: 1536950

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1536950-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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