Article
Mutational activation of N- and K-ras oncogenes in plasma cell dyscrasias.
Blood - 15 May 1993
Corradini P, Ladetto M, Voena C, Palumbo A, Inghirami G, Knowles D M, Boccadoro M, Pileri A
Abstract excerpt
The frequency of N- and K-ras oncogene mutations was investigated in plasma cell dyscrasias. Genomic DNAs from 128 patients were selected for this study: 30 monoclonal gammopathies of undetermined significance, 8 solitary plasmacytomas, 77 multiple myelomas (MM), and 13 plasma cell leukemias (PCL). A two-step experimental approach was devised. All samples were screened for mutations by single-strand conformation...
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