N-ras mutation and karyotypic evolution are closely associated with leukemic transformation in myelodysplastic syndrome.

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Article

N-ras mutation and karyotypic evolution are closely associated with leukemic transformation in myelodysplastic syndrome.

Leukemia - 1 Aug 1994

Horiike S, Misawa S, Nakai H, Kaneko H, Yokota S, Taniwaki M, Yamane Y, Inazawa J, Abe T, Kashima K

Abstract excerpt

We performed a longitudinal analysis of the karyotypes and N-ras gene configuration of bone marrow cells in 35 patients with myelodysplastic syndrome (MDS). Karyotypic evolution was found in eight patients, and was associated with disease progression, including leukemic transformation, in all the...

Topics

Adult
Aged
Aged, 80 and over
Base Sequence
Cell Transformation, Neoplastic
Chromosome Aberrations
Codon
DNA Primers
Female
Genes, ras
Humans
Karyotyping

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Leukemia

Longitudinal Studies

Male

Middle Aged

Molecular Sequence Data

Mutation

Source

Open in PubMed

Identifiers

PMID: 8057669

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-8057669-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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