Article
N-ras gene point mutations in childhood acute lymphocytic leukemia correlate with a poor prognosis.
Blood - 1 Mar 1990
Lübbert M, Mirro J, Miller C W, Kahan J, Isaac G, Kitchingman G, Mertelsmann R, Herrmann F, McCormick F, Koeffler H P
Abstract excerpt
Ras genes can be altered by point mutations at critical portions of their coding regions to acquire transforming ability in vitro. These point mutations have been detected in a variety of human malignancies. However, their relevance for the clinical and biologic behavior of the subgroups of patients exhibiting these mutations in unclear. We analyzed 100 patients with childhood acute lymphocytic leukemias (ALLs)...
Topics
- Antigens, CD
- Base Sequence
- Cell Differentiation
- Child
- Child, Preschool
- Gene Frequency
- Genes, ras
- Humans
- Infant
- Molecular Sequence Data
- Mutation