Article
A point mutation at codon 13 of the N-ras oncogene in myelodysplastic syndrome.
Nature - 1 Jan 2000
Hirai H, Kobayashi Y, Mano H, Hagiwara K, Maru Y, Omine M, Mizoguchi H, Nishida J, Takaku F
Abstract excerpt
Patients with a myelodysplastic syndrome (MDS) which has a risk of leukaemic change exhibit a variable clinical course. It has been suggested that the development of leukaemia in patients with MDS may be related to chromosomal abnormalities or genetic alterations: somatic mutation of the N-ras gene is now considered to be a critical step in the genetic basis of human leukaemogenesis. Here we report that DNAs of...
Topics
- Amino Acid Sequence
- Anemia, Refractory
- Base Sequence
- Bone Marrow
- Cell Transformation, Neoplastic
- Codon
- Humans
- Mutation
- Myelodysplastic Syndromes
- Nucleic Acid Hybridization
- Oncogenes