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Article

A point mutation at codon 13 of the N-ras oncogene in myelodysplastic syndrome.

Nature - 1 Jan 2000

Hirai H, Kobayashi Y, Mano H, Hagiwara K, Maru Y, Omine M, Mizoguchi H, Nishida J, Takaku F

Abstract excerpt

Patients with a myelodysplastic syndrome (MDS) which has a risk of leukaemic change exhibit a variable clinical course. It has been suggested that the development of leukaemia in patients with MDS may be related to chromosomal abnormalities or genetic alterations: somatic mutation of the N-ras gene is now considered to be a critical step in the genetic basis of human leukaemogenesis. Here we report that DNAs of...

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Identifiers

PMID: 3295562
DOI: 10.1038/327430a0

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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A point mutation at codon 13 of the N-ras oncogene in myelodysplastic syndrome.PMID 3295562Read ↗

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