Article
N-ras gene mutations in acute myeloid leukemia: accurate detection by solid-phase minisequencing.
International journal of cancer - 12 Mar 1992
Syvänen A C, Söderlund H, Laaksonen E, Bengtström M, Turunen M, Palotie A
Abstract excerpt
Mutations in the N-ras gene are found in one-third of patients with acute myeloid leukemia. The N-ras mutations could serve as markers for residual cells, if a highly sensitive method for detecting the mutations was available. We applied a new method, solid-phase minisequencing, to analyze bone-m...
Topics
- Base Sequence
- Genes, ras
- Humans
- Leukemia, Myeloid, Acute
- Molecular Sequence Data
- Mutation