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Article

Retrovirus-mediated insertion of expressed and non-expressed genes at identical chromosomal locations.

Nucleic acids research - 25 May 1993

Berwin B, Barklis E

Abstract excerpt

During retrovirus replication, a cellularly derived tRNA is annealed to the viral RNA at the primer binding site (PBS) to prime reverse transcription, and both the tRNA and the PBS become copied and matched together on complementary proviral DNA strands prior to integration. Using a viral PBS single base pair mutant which affects provirus expression in undifferentiated cells, we show that reversion to wild type...

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Identifiers

PMID: 8506135
DOI: 10.1093/nar/21.10.2399
PMCID: PMC309539

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