Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Characterization of large deletions occurring during a single round of retrovirus vector replication: novel deletion mechanism involving errors in strand transfer.

Journal of virology - 1 Sept 1991

Pulsinelli G A, Temin H M

Abstract excerpt

Retroviruses mutate at a high rate during replication. We used a spleen necrosis virus-based vector system and helper cell line to characterize mutations occurring during a single round of retrovirus replication. The vector used, JD216HyNeo, codes for two drug resistance genes, hygromycin resistance (hygro) and neomycin resistance (neo). The downstream neo gene is expressed only when a mutation alleviates a block...

Topics

Amino Acid Sequence
Base Sequence
Chromosome Deletion
Genetic Vectors
Molecular Sequence Data
Mutation
Oligonucleotides
Polymerase Chain Reaction
RNA-Directed DNA Polymerase
Retroviridae

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Virus Replication

Source

Open in PubMed Open full text

Identifiers

PMID: 1714517
DOI: 10.1128/JVI.65.9.4786-4797.1991
PMCID: PMC248936

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1714517-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

0

discussions

0

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Characterization of large deletions occurring during a single round of retrovirus vector replication: novel deletion mechanism involving errors in strand transfer.PMID 1714517Read ↗

Broad spectrum of in vivo forward mutations, hypermutations, and mutational hotspots in a retroviral shuttle vector after a single replication cycle: deletions and deletions with insertions.Semantic proximity Read ↗

Retroviral mutation rates and A-to-G hypermutations during different stages of retroviral replication.Semantic proximity Read ↗

High rate of genetic rearrangement during replication of a Moloney murine leukemia virus-based vector.Semantic proximity Read ↗

Determination of retroviral mutation rates using spleen necrosis virus-based vectors and helper cells.Semantic proximity Read ↗

The bovine leukemia virus encapsidation signal is discontinuous and extends into the 5' end of the gag gene.Semantic proximity Read ↗

Retroviral reverse transcription and integration: progress and problems.Semantic proximity Read ↗

Effects on DNA synthesis and translocation caused by mutations in the RNase H domain of Moloney murine leukemia virus reverse transcriptase.Semantic proximity Read ↗

A highly recombinogenic system for the recovery of infectious Sendai paramyxovirus from cDNA: generation of a novel copy‐back nondefective interfering virus.Semantic proximity Read ↗

An authentic 3' noncoding region is necessary for efficient poliovirus replication.Semantic proximity Read ↗

A respiratory syncytial virus trailer sequence modulates viral replication and the generation and propagation kinetics of copy-back defective viral genomes.Semantic proximity Read ↗

Retrovirus-mediated insertion of expressed and non-expressed genes at identical chromosomal locations.Semantic proximity Read ↗

Broad spectrum of in vivo forward mutations, hypermutations, and mutational hotspots in a retroviral shuttle vector after a single replication cycle: substitutions, frameshifts, and hypermutations.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.