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Effects of alterations of primer-binding site sequences on human immunodeficiency virus type 1 replication

1 Oct 1994

Abstract excerpt

The human immunodeficiency virus type 1 genomic RNA primer-binding site (PBS) sequence comprises 18 nucleotides which are complementary to those at the 3' end of the replication initiation primer tRNA(3Lys). To investigate the role of the PBS in viral replication, we either deleted the original wild-type PBS (complementary to tRNA(3Lys) or replaced it with DNA sequences complementary to either tRNA(1,2Lys) or...

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PMID: 7521916
DOI: 10.1128/jvi.68.10.6198-6206.1994

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Effects of alterations of primer-binding site sequences on human immunodeficiency virus type 1 replicationPMID 7521916Read ↗

Reduced replication of human immunodeficiency virus type 1 mutants that use reverse transcription primers other than the natural tRNA(3Lys).Semantic proximity Read ↗

Deletions in the tRNA(Lys) primer-binding site of human immunodeficiency virus type 1 identify essential regions for reverse transcriptionSemantic proximity Read ↗

Minimal sequence requirements of a functional human immunodeficiency virus type 1 primer binding site.Semantic proximity Read ↗

Mutations within the primer binding site of the human immunodeficiency virus type 1 define sequence requirements essential for reverse transcription.Semantic proximity Read ↗

Identification of sequences downstream of the primer binding site that are important for efficient replication of human immunodeficiency virus type 1.Semantic proximity Read ↗

Construction of a type 1 human immunodeficiency virus that maintains a primer binding site complementary to tRNA(His).Semantic proximity Read ↗

Forced selection of tRNA(Glu) reveals the importance of two adenosine-rich RNA loops within the U5-PBS for SIV(smmPBj) replication.Semantic proximity Read ↗

The tRNA primer activation signal in the human immunodeficiency virus type 1 genome is important for initiation and processive elongation of reverse transcription.Semantic proximity Read ↗

Mutations in both the U5 region and the primer-binding site influence the selection of the tRNA used for the initiation of HIV-1 reverse transcription.Semantic proximity Read ↗

Impact of forced selection of tRNAs on HIV-1 replication and genome stability highlight preferences for selection of certain tRNAs.Semantic proximity Read ↗

HIV type 1 that select tRNA(His) or tRNA(Lys1,2) as primers for reverse transcription exhibit different infectivities in peripheral blood mononuclear cells.Semantic proximity Read ↗

A structured RNA motif is involved in correct placement of the tRNA(3)(Lys) primer onto the human immunodeficiency virus genome.Semantic proximity Read ↗

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