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Article

Host cis-mediated extinction of a retrovirus permissive for expression in embryonal stem cells during differentiation.

Journal of virology - 1 Jan 1998

Laker C, Meyer J, Schopen A, Friel J, Heberlein C, Ostertag W, Stocking C

Abstract excerpt

The use of retroviral vectors for gene transfer into animals has been severely hampered by the lack of provirus transcription in the early embryo and embryonic stem (ES) cells. This primary block in provirus expression is maintained in differentiated cells by a cis-acting mechanism that is not well characterized. Retroviral vectors based on the murine embryonal stem cell virus (MESV), which overcome the...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 9420232
DOI: 10.1128/JVI.72.1.339-348.1998
PMCID: PMC109381

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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