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Article

Construction of a type 1 human immunodeficiency virus that maintains a primer binding site complementary to tRNA(His).

Journal of virology - 1 Feb 1996

Wakefield J K, Kang S M, Morrow C D

Abstract excerpt

The initiation of human immunodeficiency virus type 1 reverse transcription occurs by extension of a tRNA(Lys3) primer bound near the 5' end of the viral RNA genome which is designated the primer binding site (PBS). Sequences within the viral genome upstream of the PBS which are complementary to the anticodon loop (USUU) and the T psi C loop and arm (AGGGTm psi) of tRNA(Lys3) are postulated to play a role in...

Read the complete abstract on PubMed

Topics

Animals
Anticodon
Base Sequence
Binding Sites
Cell Line
DNA Primers
DNA, Viral

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Genome, Viral

HIV-1

Humans

Molecular Sequence Data

Mutation

Nucleic Acid Conformation

Proviruses

RNA, Transfer, His

RNA, Transfer, Lys

RNA, Viral

Structure-Activity Relationship

Source

Open in PubMed Open full text

Identifiers

PMID: 8551637
DOI: 10.1128/JVI.70.2.966-975.1996
PMCID: PMC189901

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

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Click a neighbor to travelStep 1 · 12 closest

Construction of a type 1 human immunodeficiency virus that maintains a primer binding site complementary to tRNA(His).PMID 8551637Read ↗

Minimal sequence requirements of a functional human immunodeficiency virus type 1 primer binding site.Semantic proximity Read ↗

Mutations within the primer binding site of the human immunodeficiency virus type 1 define sequence requirements essential for reverse transcription.Semantic proximity Read ↗

Effects of alterations of primer-binding site sequences on human immunodeficiency virus type 1 replicationSemantic proximity Read ↗

Nucleotide substitutions within U5 are critical for efficient reverse transcription of human immunodeficiency virus type 1 with a primer binding site complementary to tRNA(His).Semantic proximity Read ↗

Mutations in both the U5 region and the primer-binding site influence the selection of the tRNA used for the initiation of HIV-1 reverse transcription.Semantic proximity Read ↗

Deletions in the tRNA(Lys) primer-binding site of human immunodeficiency virus type 1 identify essential regions for reverse transcriptionSemantic proximity Read ↗

Forced selection of tRNA(Glu) reveals the importance of two adenosine-rich RNA loops within the U5-PBS for SIV(smmPBj) replication.Semantic proximity Read ↗

Genetic analysis of the U5-PBS of a novel HIV-1 reveals multiple interactions between the tRNA and RNA genome required for initiation of reverse transcription.Semantic proximity Read ↗

Reduced replication of human immunodeficiency virus type 1 mutants that use reverse transcription primers other than the natural tRNA(3Lys).Semantic proximity Read ↗

HIV type 1 that select tRNA(His) or tRNA(Lys1,2) as primers for reverse transcription exhibit different infectivities in peripheral blood mononuclear cells.Semantic proximity Read ↗

Impact of forced selection of tRNAs on HIV-1 replication and genome stability highlight preferences for selection of certain tRNAs.Semantic proximity Read ↗

The tRNA primer activation signal in the human immunodeficiency virus type 1 genome is important for initiation and processive elongation of reverse transcription.Semantic proximity Read ↗

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