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Deletions in the tRNA(Lys) primer-binding site of human immunodeficiency virus type 1 identify essential regions for reverse transcription

1 Sept 1991

Abstract excerpt

The initiation of human immunodeficiency virus type 1 (HIV-1) reverse transcription occurs by the extension of a tRNA primer bound near the 5' end of the genomic RNA at a position termed the primer-binding site (PBS). The PBS is an 18-nucleotide region of the HIV-1 genome complementary to cellular tRNA(Lys). To further investigate the sequence requirements for the PBS in reverse transcription, deletions in the...

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Identifiers

PMID: 1714513
DOI: 10.1128/jvi.65.9.4555-4564.1991

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Related research

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

Deletions in the tRNA(Lys) primer-binding site of human immunodeficiency virus type 1 identify essential regions for reverse transcriptionPMID 1714513Read ↗

Effects of alterations of primer-binding site sequences on human immunodeficiency virus type 1 replicationSemantic proximity Read ↗

Minimal sequence requirements of a functional human immunodeficiency virus type 1 primer binding site.Semantic proximity Read ↗

Mutations within the primer binding site of the human immunodeficiency virus type 1 define sequence requirements essential for reverse transcription.Semantic proximity Read ↗

Mutations in both the U5 region and the primer-binding site influence the selection of the tRNA used for the initiation of HIV-1 reverse transcription.Semantic proximity Read ↗

Identification of sequences downstream of the primer binding site that are important for efficient replication of human immunodeficiency virus type 1.Semantic proximity Read ↗

Construction of a type 1 human immunodeficiency virus that maintains a primer binding site complementary to tRNA(His).Semantic proximity Read ↗

The tRNA primer activation signal in the human immunodeficiency virus type 1 genome is important for initiation and processive elongation of reverse transcription.Semantic proximity Read ↗

Reduced replication of human immunodeficiency virus type 1 mutants that use reverse transcription primers other than the natural tRNA(3Lys).Semantic proximity Read ↗

Forced selection of tRNA(Glu) reveals the importance of two adenosine-rich RNA loops within the U5-PBS for SIV(smmPBj) replication.Semantic proximity Read ↗

A structured RNA motif is involved in correct placement of the tRNA(3)(Lys) primer onto the human immunodeficiency virus genome.Semantic proximity Read ↗

Initiation of HIV-1 Reverse Transcription Is Regulated by a Primer Activation SignalSemantic proximity Read ↗

Essential regions of the tRNA primer required for HIV-1 infectivity.Semantic proximity Read ↗

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