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Article

Murine leukemia virus with a primer-binding site complementary to tRNALys,3 adapts to select new tRNAs for replication following extended in vitro culture.

Virology - 15 Mar 2005

Palmer Matthew T, McPherson Sylvia, Morrow Casey D

Abstract excerpt

The preference of MuLV for the selection of tRNA(Pro) as a replication primer was investigated by altering the primer-binding site (PBS) to be complementary to tRNA(Lys,3). MuLV-based vectors with a PBS complementary to tRNA(Lys,3) were found to be approximately 2-fold less infectious than vectors with the wild-type PBS complementary to tRNA(Pro). MuLV with a PBS complementary to tRNA(Lys,3) was replication...

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Share to Adaptation, Physiological
Share to DNA, Viral

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Leukemia Virus, Murine

Share to Nucleic Acid Conformation

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Share to RNA, Transfer, Lys

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Source

Identifiers

PMID: 15721366
DOI: 10.1016/j.virol.2004.12.033

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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