Infrequent mutation of p53 gene in human renal cell carcinoma detected by polymerase chain reaction single-strand conformation polymorphism analysis.

doi:10.1111/j.1349-7006.1992.tb00091.x

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Article

Infrequent mutation of p53 gene in human renal cell carcinoma detected by polymerase chain reaction single-strand conformation polymorphism analysis.

Japanese journal of cancer research : Gann - 1 Mar 1992

Suzuki Y, Tamura G, Satodate R, Fujioka T

Abstract excerpt

Mutation of the p53 gene, which plays an important role in the genesis of diverse human cancers, was investigated in 23 surgical specimens of human renal cell carcinoma using the polymerase chain reaction single-strand conformation polymorphism method of analysis. Only one of the 23 tumors (4.3%)...

Topics

Amino Acid Sequence
Carcinoma, Renal Cell
DNA, Single-Stranded
Genes, p53
Humans
Kidney Neoplasms
Molecular Sequence Data
Mutation
Polymerase Chain Reaction

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