Alteration of p53 gene in ovarian carcinoma: clinicopathological correlation and prognostic significance.

doi:10.1038/bjc.1994.472

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Article

Alteration of p53 gene in ovarian carcinoma: clinicopathological correlation and prognostic significance.

British journal of cancer - 1 Dec 1994

Niwa K, Itoh M, Murase T, Morishita S, Itoh N, Mori H, Tamaya T

Abstract excerpt

Inactivation of the tumour-suppressor gene p53 has been demonstrated in a variety of human tumours. We extracted DNA from paraffin-embedded tissues of 67 ovarian carcinoma samples (54 primary tumours, seven metastases and six tumours obtained after chemotherapy), and analysed allelic losses and mutations of the p53 gene using single-strand conformation polymorphism (SSCP) analysis of DNA fragments amplified by a...

Topics

Adenocarcinoma, Clear Cell
Alleles
Base Sequence
Carcinoma
Carcinoma, Squamous Cell
Cell Differentiation
Cystadenocarcinoma, Serous
DNA Primers
Endometrial Neoplasms
Female
Gene Deletion

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Genes, p53

Humans

Middle Aged

Molecular Sequence Data

Mutation

Ovarian Neoplasms

Polymorphism, Genetic

Source

Open in PubMed Open full text

Identifiers

PMID: 7981076
DOI: 10.1038/bjc.1994.472
PMCID: PMC2033683

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-7981076-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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