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Article

Spectrum of mutation and frequency of allelic deletion of the p53 gene in ovarian cancer.

Journal of the National Cancer Institute - 15 Sept 1993

Kohler M F, Marks J R, Wiseman R W, Jacobs I J, Davidoff A M, Clarke-Pearson D L, Soper J T, Bast R C, Berchuck A

Abstract excerpt

BACKGROUND: The p53 gene encodes a nuclear phosphoprotein present in low levels in normal human cells. The wild-type form of this protein functions to restrain inappropriate cellular proliferation. Approximately one half of human epithelial ovarian cancers have mutations in the p53 gene and overexpress the mutant protein product. Deletion of one allele of the p53 gene also frequently occurs in these cancers....

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Identifiers

PMID: 8360934
DOI: 10.1093/jnci/85.18.1513

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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