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Article

Spectrum of mutation and frequency of allelic deletion of the p53 gene in ovarian cancer.

Journal of the National Cancer Institute - 15 Sept 1993

Kohler M F, Marks J R, Wiseman R W, Jacobs I J, Davidoff A M, Clarke-Pearson D L, Soper J T, Bast R C, Berchuck A

Abstract excerpt

BACKGROUND: The p53 gene encodes a nuclear phosphoprotein present in low levels in normal human cells. The wild-type form of this protein functions to restrain inappropriate cellular proliferation. Approximately one half of human epithelial ovarian cancers have mutations in the p53 gene and overe...

Topics

Alleles
Amino Acid Sequence
Base Sequence
Factor IX
Female
Genes, p53
Humans
Molecular Sequence Data
Oligodeoxyribonucleotides
Ovarian Neoplasms
Point Mutation
Sequence Deletion

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Identifiers

PMID: 8360934
DOI: 10.1093/jnci/85.18.1513

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-8360934-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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