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Article

High frequency of K-ras mutations in sporadic colorectal adenomas.

Gut - 1 Mar 1993

McLellan E A, Owen R A, Stepniewska K A, Sheffield J P, Lemoine N R

Abstract excerpt

The frequency of activating mutations at codons 12 and 13 of the K-ras gene was investigated in 57 sporadic adenomas from 47 patients using the polymerase chain reaction and oligonucleotide hybridisation assay. Sixty eight per cent of the adenomas tested were positive for K-ras mutations. This high frequency, combined with the lack of a correlation between mutations and adenoma size, suggest that K-ras mutations...

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Identifiers

PMID: 8472989
DOI: 10.1136/gut.34.3.392
PMCID: PMC1374148

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FAP

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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