Article
High frequency of K-ras mutations in sporadic colorectal adenomas.
Gut - 1 Mar 1993
McLellan E A, Owen R A, Stepniewska K A, Sheffield J P, Lemoine N R
Abstract excerpt
The frequency of activating mutations at codons 12 and 13 of the K-ras gene was investigated in 57 sporadic adenomas from 47 patients using the polymerase chain reaction and oligonucleotide hybridisation assay. Sixty eight per cent of the adenomas tested were positive for K-ras mutations. This hi...
Topics
- Adenoma
- Adult
- Aged
- Aged, 80 and over
- Base Sequence
- Colorectal Neoplasms
- DNA Mutational Analysis
- Female
- Gene Amplification
- Genes, ras
- Humans
- Male
- Middle Aged
- Molecular Sequence Data
- Mutation