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Article

Frequent and characteristic K-ras activation in aberrant crypt foci of colon. Is there preference among K-ras mutants for malignant progression?

Cancer - 15 Mar 1995

Yamashita N, Minamoto T, Ochiai A, Onda M, Esumi H

Abstract excerpt

BACKGROUND: To investigate very early lesion of colorectal cancer, K-ras activation and nuclear p53 accumulation were studied in aberrant crypt focus (ACF). METHODS: ACF were microscopically identified in grossly normal mucosa of patients with colorectal cancer who underwent surgery. Each ACF was microdissected from the surgical specimen and divided into two pieces, one for histologic and immunohistochemical...

Topics

Adenocarcinoma
Adult
Aged
Base Sequence
Colorectal Neoplasms
Female
Gene Expression Regulation, Neoplastic
Genes, ras
Humans
Male
Middle Aged
Molecular Sequence Data

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Mutation

Polymerase Chain Reaction

Polymorphism, Restriction Fragment Length

Tumor Suppressor Protein p53

Source

Identifiers

PMID: 7889486
DOI: 10.1002/1097-0142(19950315)75:6+<1527::aid-cncr2820751524>3.0.co;2-y

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-7889486-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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