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Article

Lower incidence of K-ras codon 12 mutation in flat colorectal adenomas than in polypoid adenomas.

Japanese journal of cancer research : Gann - 1 Feb 1994

Yamagata S, Muto T, Uchida Y, Masaki T, Sawada T, Tsuno N, Hirooka T

Abstract excerpt

In order to clarify genetic changes in flat adenomas, K-ras codon 12 point mutations were examined in 56 flat adenomas, 81 polypoid adenomas and 42 cancers of colon and rectum. The mutation frequency in flat adenomas was 23% (13/56), significantly lower than that in polypoid adenomas (67%: 54/81)...

Topics

Adenoma
Adenomatous Polyps
Base Sequence
Colorectal Neoplasms
DNA Mutational Analysis
DNA Primers
DNA, Neoplasm
Gene Frequency
Genes, ras
Humans
Molecular Sequence Data
Mutation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Polymerase Chain Reaction

Sensitivity and Specificity

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Identifiers

PMID: 8144396
DOI: 10.1111/j.1349-7006.1994.tb02075.x
PMCID: PMC5919417

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-8144396-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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