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Article

Lower incidence of K-ras codon 12 mutation in flat colorectal adenomas than in polypoid adenomas.

Japanese journal of cancer research : Gann - 1 Feb 1994

Yamagata S, Muto T, Uchida Y, Masaki T, Sawada T, Tsuno N, Hirooka T

Abstract excerpt

In order to clarify genetic changes in flat adenomas, K-ras codon 12 point mutations were examined in 56 flat adenomas, 81 polypoid adenomas and 42 cancers of colon and rectum. The mutation frequency in flat adenomas was 23% (13/56), significantly lower than that in polypoid adenomas (67%: 54/81) and cancers (76%: 32/42). Even mildly dysplastic adenomas or small (less than 5 mm) adenomas showed higher mutation...

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Identifiers

PMID: 8144396
DOI: 10.1111/j.1349-7006.1994.tb02075.x
PMCID: PMC5919417

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Source receipt: pubmed, retrieved 7 Sept 2026.

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