K-ras activation in colorectal tumors from patients with familial polyposis coli.

Abstract excerpt

K-ras gene mutation in colorectal tumors from patients with familial polyposis coli were investigated using oligonucleotide probes specific for a mutation at codon 12, 13, or 61 of the K-ras gene. The authors examined 22 colorectal carcinomas and 51 colorectal adenomas from 41 familial polyposis coli patients and observed mutations at codons 12 and 13 in eight of 22 colorectal carcinomas (36%) and six of 51...

Topics

• Adenomatous Polyposis Coli
• Base Sequence
• Codon
• Colorectal Neoplasms
• Gene Expression Regulation
• Genes, ras
• Humans
• Molecular Sequence Data
• Mutation