Article
K-ras mutations in incident sporadic colorectal adenomas.
Cancer - 1 Mar 2006
Barry Elizabeth L R, Baron John A, Grau Maria V, Wallace Kristin, Haile Robert W
Abstract excerpt
BACKGROUND: Although K-ras is the most frequently mutated protooncogene in colorectal carcinoma, the specific role and timing of K-ras mutations in colorectal carcinogenesis remains controversial. In the current study, the authors investigated associations with K-ras mutation in incident sporadic colorectal adenomas that occurred during a chemoprevention trial of calcium supplementation. METHODS: K-ras genotyping...
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