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Article

K-ras AND p53 MUTATIONS IN HUMAN COLORECTAL ABERRANT CRYPT FOCI

1 Mar 1996

Abstract excerpt

Aberrant crypt foci (ACF) are putative precursor lesions of colon cancer, recently identified on the methylene blue-stained mucosal surface of human colon. No mutations in K-ras or p53 genes were found by non-radioactive single-strand conformation polymorphism analysis in 14 ACF collected from five patients. Using the more sensitive method of allele-specific polymerase chain reaction (PCR) for K-ras, 8 of 14 ACF...

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PMID: 8778329
DOI: 10.1002/(sici)1096-9896(199603)178:3<259::aid-path473>3.0.co;2-4

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Source receipt: pubmed, retrieved 7 Sept 2026.

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