K-ras gene mutation in colorectal adenomas and carcinomas from familial adenomatous polyposis patients.

doi:10.1016/0960-7404(92)90087-2

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Article

K-ras gene mutation in colorectal adenomas and carcinomas from familial adenomatous polyposis patients.

Surgical oncology - 1 Aug 1992

Boughdady I S, Kinsella A R, Haboubi N Y, Schofield P F

Abstract excerpt

Colorectal adenomas and carcinomas from familial adenomatous polyposis (FAP) patients were screened for the presence of K-ras gene mutations at codon 12 using an in vitro amplification step (polymerase chain reaction) followed by dot blot analysis using oligonucleotide probes specific for differe...

Topics

Adenoma
Adenomatous Polyposis Coli
Adult
Base Sequence
Carcinoma
Child
Codon
Colorectal Neoplasms
DNA
Female
Genes, ras
Humans
Immunoblotting
Male
Middle Aged
Molecular Sequence Data
Mutation
Nucleic Acid Hybridization

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