Article
K-ras gene mutation in colorectal adenomas and carcinomas from familial adenomatous polyposis patients.
Surgical oncology - 1 Aug 1992
Boughdady I S, Kinsella A R, Haboubi N Y, Schofield P F
Abstract excerpt
Colorectal adenomas and carcinomas from familial adenomatous polyposis (FAP) patients were screened for the presence of K-ras gene mutations at codon 12 using an in vitro amplification step (polymerase chain reaction) followed by dot blot analysis using oligonucleotide probes specific for different mutations at codon 12. We examined 28 colorectal adenomas and two colorectal carcinomas from 12 FAP patients and...
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