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Article

Genetic and biochemical analyses of yeast TATA-binding protein mutants.

The Journal of biological chemistry - 5 Mar 1993

Poon D, Knittle R A, Sabelko K A, Yamamoto T, Horikoshi M, Roeder R G, Weil P A

Abstract excerpt

We have taken a combined genetic and biochemical approach to study TATA-binding protein (TBP) structure-function relationships. Using site-directed mutagenesis coupled with a screen for conditional lethal growth, we have isolated a number of temperature-sensitive TBP alleles in the region of amino acid positions 188, 189, and 190. Conditional growth is not a result of increased TBP turnover as most of the mutant...

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Source

Identifiers

PMID: 8444878

Genes

TBP

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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