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Article

TATA-binding protein variants that bypass the requirement for Mot1 in vivo.

The Journal of biological chemistry - 13 Feb 2009

Sprouse Rebekka O, Wells Melissa N, Auble David T

Abstract excerpt

Mot1 is an essential TATA-binding protein (TBP)-associated factor and Snf2/Swi2 ATPase that both represses and activates transcription. Biochemical and structural results support a model in which ATP binding and hydrolysis induce a conformational change in Mot1 that drives local translocation along DNA, thus removing TBP. Although this activity explains transcriptional repression, it does not as easily explain...

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Identifiers

PMID: 19098311
DOI: 10.1074/jbc.M808951200
PMCID: PMC2640957

Genes

TBP

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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TATA-binding protein variants that bypass the requirement for Mot1 in vivo.PMID 19098311Read ↗

Genome-wide transcriptional dependence on conserved regions of Mot1.Semantic proximity Read ↗

Molecular analysis of the SNF2/SWI2 protein family member MOT1, an ATP-driven enzyme that dissociates TATA-binding protein from DNA.Semantic proximity Read ↗

Regulation of rRNA synthesis by TATA-binding protein-associated factor Mot1.Semantic proximity Read ↗

Genetic analysis connects SLX5 and SLX8 to the SUMO pathway in Saccharomyces cerevisiae.Semantic proximity Read ↗

Analysis of TFIIA function In vivo: evidence for a role in TATA-binding protein recruitment and gene-specific activation.Semantic proximity Read ↗

Isw1 functions in parallel with the NuA4 and Swr1 complexes in stress-induced gene repression.Semantic proximity Read ↗

A new regulatory domain on the TATA-binding protein.Semantic proximity Read ↗

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Broad, but not universal, transcriptional requirement for yTAFII17, a histone H3-like TAFII present in TFIID and SAGA.Semantic proximity Read ↗

Multiple regions of TBP participate in the response to transcriptional activators in vivo.Semantic proximity Read ↗

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The NOT, SPT3, and MOT1 genes functionally interact to regulate transcription at core promoters.Semantic proximity Read ↗

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