Article
TATA-binding protein variants that bypass the requirement for Mot1 in vivo.
The Journal of biological chemistry - 13 Feb 2009
Sprouse Rebekka O, Wells Melissa N, Auble David T
Abstract excerpt
Mot1 is an essential TATA-binding protein (TBP)-associated factor and Snf2/Swi2 ATPase that both represses and activates transcription. Biochemical and structural results support a model in which ATP binding and hydrolysis induce a conformational change in Mot1 that drives local translocation along DNA, thus removing TBP. Although this activity explains transcriptional repression, it does not as easily explain...
Topics
- Adenosine Triphosphatases
- Adenosine Triphosphate
- Chromatin
- DNA Helicases
- DNA Polymerase II
- DNA-Binding Proteins
- Mutation
- Promoter Regions, Genetic
- Protein Binding
- Saccharomyces cerevisiae
- Saccharomyces cerevisiae Proteins
- TATA-Binding Protein Associated Factors
- Transcription Factors
- Transcription, Genetic