Article
Conserved and nonconserved functions of the yeast and human TATA-binding proteins.
Genes & development - 1 Jun 1994
Cormack B P, Strubin M, Stargell L A, Struhl K
Abstract excerpt
Although the TATA-binding protein (TBP) is highly conserved throughout the eukaryotic kingdom, human TBP cannot functionally replace yeast TBP for cell viability. To investigate the basis of this species specificity, we examine the in vivo transcriptional activity of human TBP at different classe...
Topics
- Amino Acid Sequence
- Base Sequence
- DNA-Binding Proteins
- DNA-Directed RNA Polymerases
- Humans
- Molecular Sequence Data
- Mutation
- Promoter Regions, Genetic
- Saccharomyces cerevisiae
- Species Specificity
- TATA Box
- TATA-Box Binding Protein
- Transcription Factors
- Transcription, Genetic