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Article

Conserved and nonconserved functions of the yeast and human TATA-binding proteins.

Genes & development - 1 Jun 1994

Cormack B P, Strubin M, Stargell L A, Struhl K

Abstract excerpt

Although the TATA-binding protein (TBP) is highly conserved throughout the eukaryotic kingdom, human TBP cannot functionally replace yeast TBP for cell viability. To investigate the basis of this species specificity, we examine the in vivo transcriptional activity of human TBP at different classes of yeast promoters. Consistent with previous results, analysis of yeast/human hybrid TBPs indicates that growth...

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Source

Identifiers

PMID: 7926734
DOI: 10.1101/gad.8.11.1335

Genes

TBP

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Conserved and nonconserved functions of the yeast and human TATA-binding proteins.PMID 7926734Read ↗

Multiple regions of TBP participate in the response to transcriptional activators in vivo.Semantic proximity Read ↗

Mutations on the DNA binding surface of TBP discriminate between yeast TATA and TATA-less gene transcription.Semantic proximity Read ↗

A severely defective TATA-binding protein-TFIIB interaction does not preclude transcriptional activation in vivo.Semantic proximity Read ↗

Genome-wide transcriptional dependence on conserved regions of Mot1.Semantic proximity Read ↗

Yeast and human TATA-binding proteins have nearly identical DNA sequence requirements for transcription in vitro.Semantic proximity Read ↗

Genetic and biochemical analyses of yeast TATA-binding protein mutants.Semantic proximity Read ↗

Distinct mutations in yeast TAF(II)25 differentially affect the composition of TFIID and SAGA complexes as well as global gene expression patterns.Semantic proximity Read ↗

TBP-associated factors are not generally required for transcriptional activation in yeast.Semantic proximity Read ↗

Multiple functions of the nonconserved N-terminal domain of yeast TATA-binding protein.Semantic proximity Read ↗

Functional interchangeability of TFIIIB components from yeast and human cells in vitro.Semantic proximity Read ↗

Broad, but not universal, transcriptional requirement for yTAFII17, a histone H3-like TAFII present in TFIID and SAGA.Semantic proximity Read ↗

A TATA binding protein mutant with increased affinity for DNA directs transcription from a reversed TATA sequence in vivo.Semantic proximity Read ↗

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