Article
A new regulatory domain on the TATA-binding protein.
The EMBO journal - 1 Dec 1999
Cang Y, Auble D T, Prelich G
Abstract excerpt
Recognition of the TATA box by the TATA-binding protein (TBP) is a highly regulated step in RNA polymerase II-dependent transcription. Several proteins have been proposed to regulate TBP activity, yet the TBP domains responsive to all these regulators have not been defined. Here we describe a new class of TBP mutants that increase transcription from core promoters in vivo. The majority of these mutations alter...
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