Article
A severely defective TATA-binding protein-TFIIB interaction does not preclude transcriptional activation in vivo.
Molecular and cellular biology - 1 Mar 1997
Lee M, Struhl K
Abstract excerpt
In yeast cells, mutations in the TATA-binding protein (TBP) that disrupt the interaction with the TATA element or with TFIIA can selectively impair the response to acidic activator proteins. We analyzed the transcriptional properties of TBP derivatives in which residues that directly interact wit...
Topics
- Alanine
- Amino Acid Sequence
- Conserved Sequence
- DNA-Binding Proteins
- Humans
- Mutation
- Phenotype
- Protein Binding
- RNA Polymerase II
- Sequence Homology, Amino Acid
- TATA-Box Binding Protein
- Transcription Factor TFIIA
- Transcription Factor TFIIB
- Transcription Factors
- Transcriptional Activation
- Yeasts