Article
TBP mutants defective in activated transcription in vivo.
The EMBO journal - 3 Apr 1995
Arndt K M, Ricupero-Hovasse S, Winston F
Abstract excerpt
The TATA box binding protein (TBP) plays a central and essential role in transcription initiation. At TATA box-containing genes transcribed by RNA polymerase II, TBP binds to the promoter and initiates the assembly of a multiprotein preinitiation complex. Several studies have suggested that binding of TBP to the TATA box is an important regulatory step in transcription initiation in vitro. To determine whether...
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