Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Mutations on the DNA binding surface of TBP discriminate between yeast TATA and TATA-less gene transcription.

Molecular and cellular biology - 1 Aug 2014

Kamenova Ivanka, Warfield Linda, Hahn Steven

Abstract excerpt

Most RNA polymerase (Pol) II promoters lack a TATA element, yet nearly all Pol II transcription requires TATA binding protein (TBP). While the TBP-TATA interaction is critical for transcription at TATA-containing promoters, it has been unclear whether TBP sequence-specific DNA contacts are required for transcription at TATA-less genes. Transcription factor IID (TFIID), the TBP-containing coactivator that...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to DNA-Binding Proteins
Share to Promoter Regions, Genetic
Share to Ribosomal Proteins

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to TATA Box

Share to TATA-Box Binding Protein

Share to Transcription Factor TFIID

Share to Transcription, Genetic

Share to Yeasts

Source

Open in PubMed Open full text

Identifiers

PMID: 24865972
DOI: 10.1128/MCB.01685-13
PMCID: PMC4135567

Genes

TBP

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Mutations on the DNA binding surface of TBP discriminate between yeast TATA and TATA-less gene transcription.PMID 24865972Read ↗

A new regulatory domain on the TATA-binding protein.Semantic proximity Read ↗

TBP-associated factors are not generally required for transcriptional activation in yeast.Semantic proximity Read ↗

A TATA binding protein mutant with increased affinity for DNA directs transcription from a reversed TATA sequence in vivo.Semantic proximity Read ↗

Multiple regions of TBP participate in the response to transcriptional activators in vivo.Semantic proximity Read ↗

Conserved and nonconserved functions of the yeast and human TATA-binding proteins.Semantic proximity Read ↗

Connecting a promoter-bound protein to TBP bypasses the need for a transcriptional activation domain.Semantic proximity Read ↗

Analysis of TFIIA function In vivo: evidence for a role in TATA-binding protein recruitment and gene-specific activation.Semantic proximity Read ↗

Yeast and human TATA-binding proteins have nearly identical DNA sequence requirements for transcription in vitro.Semantic proximity Read ↗

Mutations on the DNA-binding surface of TATA-binding protein can specifically impair the response to acidic activators in vivo.Semantic proximity Read ↗

Association of transcription factor IIA with TATA binding protein is required for transcriptional activation of a subset of promoters and cell cycle progression in Saccharomyces cerevisiae.Semantic proximity Read ↗

Genome-wide transcriptional dependence on conserved regions of Mot1.Semantic proximity Read ↗

Distinct mutations in yeast TAF(II)25 differentially affect the composition of TFIID and SAGA complexes as well as global gene expression patterns.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.