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Article

Distinct pattern of p53 mutations in bladder cancer: relationship to tobacco usage.

Cancer research - 1 Mar 1993

Spruck C H, Rideout W M, Olumi A F, Ohneseit P F, Yang A S, Tsai Y C, Nichols P W, Horn T, Hermann G G, Steven K

Abstract excerpt

A distinct mutational spectrum for the p53 tumor suppressor gene in bladder carcinomas was established in patients with known exposures to cigarette smoke. Single-strand conformational polymorphism analysis of exons 5 through 8 of the p53 gene showed inactivating mutations in 16 of 40 (40%) bladder tumors from smokers and 13 of 40 (33%) tumors from lifetime nonsmokers. Overall, 13 of the 50 (26%) total point...

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Identifiers

PMID: 8439962

Genes

AGA

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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